Science
Mechanism of Action
It functions as a Histone Deacetylase (HDAC) inhibitor, specifically upregulating H4K16 acetylation to stimulate cellular proliferation and differentiation. This epigenetic action speeds up wound healing and stratum corneum thickening while simultaneously inhibiting P. acnes growth and suppressing pro-inflammatory cytokines like IL-6 and IL-8.
Research
Clinical Evidence
High confidence4%
Key findings
- 01 A 4% concentration demonstrated a 40% increase in tissue repair markers (bud length) and complete inhibition of P. acnes within 24 hours.
- 02 A 2% concentration improved stratum corneum thickness and increased tissue repair by 17% by the third day of application.
- 03 A 60-subject multicentric trial confirmed significant reduction in inflammatory lesions (papules/pustules) and comedones over a 60-day period.
Transparency
Dusting Analysis
Because it is a relatively new and premium patented ingredient (often known as Epi-On), it is frequently 'dusted' at sub-clinical levels below 2% to claim benefits without providing the actual regenerative or antimicrobial results seen in clinical data.
The Formula
Formulation
Stability
Highly stable within the physiological pH range; however, formulations should be protected from direct light and moisture to maintain the integrity of the active solution.
Synergies
- Niacinamide
- Salicylic Acid
- Hyaluronic Acid
Safety
Safety Profile
Classified within the fatty acid amidopropyl dimethylamines group; recognized as safe when formulated to be non-sensitizing. Approved for use by the NMPA in 2022.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A high-performance active that offers a sophisticated, non-irritating alternative to traditional blemish treatments by focusing on epigenetic healing and microbiome balance.
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