Science
Mechanism of Action
This extract functions through a dual-action pathway: it utilizes a rich profile of flavonoids like apigenin and quercetin to neutralize oxidative stress and inhibit pro-inflammatory cytokines such as TNF-α and IL-6. Simultaneously, it stimulates the synthesis of Type I pro-collagen in dermal fibroblasts and acts as a natural humectant to optimize moisture levels within the stratum corneum.
Research
Clinical Evidence
High confidence0.1%
Key findings
- 01 In vitro testing demonstrated that a 0.1% concentration significantly elevated the production of pro-collagen I, suggesting a direct impact on skin density.
- 02 In vivo research recorded a 73% reduction in inflammatory edema, highlighting its potent soothing capabilities.
- 03 Comparative assays identified an IC50 of 80.35 μg/mL for lipid peroxidation inhibition, placing its antioxidant capacity on par with pure quercetin.
Transparency
Dusting Analysis
While this ingredient is effective at low concentrations, many formulas include it at 'trace' levels (below 0.01%) purely for marketing claims. To achieve measurable collagen-boosting and anti-inflammatory results, look for concentrations between 0.1% and 1.0%.
The Formula
Formulation
Stability
Highly stable at room temperature in water or polyol-based systems (Glycerin/Butylene Glycol). It is sensitive to thermal degradation and should be added during the cooling phase of production.
Synergies
- Vitamin C
- Hyaluronic Acid
- Peptides
Conflicts
- Strong oxidizing agents
- Extreme pH levels (can cause flavonoid-induced color shifts)
Safety
Safety Profile
Recognized as safe for use in international cosmetic markets, including the IECIC. It is generally regarded as non-irritating even in sensitive skin applications.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A high-performance botanical that bridges the gap between soothing hydration and structural anti-aging, provided it is used at clinically relevant concentrations.
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References
Sources