Science
Mechanism of Action
This extract operates through a multi-dimensional biological pathway: it upregulates the Hyaluronic Acid Synthase-3 (HAS-3) gene to increase endogenous moisture levels and stimulates the migration of fibroblasts and keratinocytes to expedite structural repair. Its high polysaccharide content forms a breathable film to lock in hydration, while its phenolic compounds neutralize reactive oxygen species and inhibit pro-inflammatory signaling.
Research
Clinical Evidence
High confidence2.5%
Key findings
- 01 Demonstrated a 30% increase in Hyaluronic Acid Synthase-3 (HAS-3) expression and boosted procollagen biosynthesis in human keratinocytes.
- 02 Achieved significant acceleration of wound closure and cellular proliferation in vivo by day 12 at concentrations up to 2.5%.
- 03 Exhibited potent antioxidant capacity with an IC50 of 0.309 mg/mL, effectively outperforming standard methanol-based extracts.
Transparency
Dusting Analysis
While frequently included in 'mushroom-themed' marketing, this ingredient is often used at sub-clinical levels. To achieve the documented 30% boost in hyaluronic acid synthesis and wound healing benefits, a concentration of at least 1.0% is required.
The Formula
Formulation
Stability
Highly stable at room temperature and neutral pH; however, viscosity may degrade if exposed to temperatures exceeding 50°C in very acidic or alkaline environments.
Synergies
- Panthenol
- Glycerin
- L-Ascorbic Acid
- Ceramides
Conflicts
- Prolonged high-heat processing
Safety
Safety Profile
Classified as Generally Recognized as Safe (GRAS) given its long history as an edible fungus; no dermal irritation or systemic toxicity has been documented.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A potent, non-irritating botanical that offers a rare combination of significant hyaluronic acid upregulation and rapid tissue regeneration.
Related
Similar Ingredients
Finding similar ingredients…
References
Sources