Science
Mechanism of Action
This ferment synthesizes a matrix of extracellular polysaccharides, specifically pullulan and beta-glucans, which create a breathable, non-occlusive shield against environmental pollutants. Beyond surface protection, it optimizes cellular energy by elevating the NAD+/NADH ratio and stimulates structural proteins like involucrin to densify the epidermal barrier while suppressing inflammatory markers like IL-1α.
Research
Clinical Evidence
High confidence1%
Key findings
- 01 Topical 10% concentration demonstrated significant improvement in barrier function and a measurable reduction in reactive skin sensitivity in Estée Lauder research.
- 02 Low-dose applications (0.1-1%) are clinically proven to smooth skin microrelief and increase the synthesis of essential epidermal cohesion markers.
- 03 Oral supplementation studies (250mg) further validate its systemic ability to reduce transepidermal water loss and manage atopic dermatitis severity.
Transparency
Dusting Analysis
Because it is effective at very low concentrations (0.1%), brands often include it at 'label claim' levels (below 0.05%) that fail to trigger the NAD+ metabolic boost or structural protein synthesis found in manufacturer data.
The Formula
Formulation
Stability
Exhibits 'polyextremotolerance,' maintaining structural integrity across extreme pH levels and high electrolyte environments. Its non-ionic nature allows it to act as a secondary emulsion stabilizer.
Synergies
- Hyaluronic Acid
- Niacinamide
- Ceramides
- Antioxidants
Safety
Safety Profile
Recognized as safe under the CIR assessments for yeast-derived ingredients; the resulting pullulan is FDA GRAS rated.
Your Skin
Skin Compatibility
Our Assessment
Verdict
An exceptionally stable, biotech-derived shield that provides both immediate surface smoothing and long-term biological barrier reinforcement.
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References
Sources