Science
Mechanism of Action
This extract operates through a multi-pathway approach: it inhibits melanogenesis by downregulating key enzymes like Tyrosinase and TRP-1/2 via the MEK/ERK and AKT signaling routes. Concurrently, it protects the dermal matrix by suppressing elastase and matrix metalloproteinases (MMP-1, 3, 9) while boosting Filaggrin and Hyaluronic Acid Synthase 2 to enhance internal hydration and barrier integrity.
Research
Clinical Evidence
High confidence68.6%
Key findings
- 01 In a targeted 8-week clinical trial involving 22 subjects with facial hyperpigmentation, a cream formulated with 68.6% Aster Yomena Callus Extract achieved a significant 8.68% reduction in the melanin index.
Transparency
Dusting Analysis
Because high-purity callus extracts are premium raw materials, they are frequently 'dusted' at concentrations below 1% for marketing claims. However, clinical evidence suggests significant pigment correction and barrier benefits are optimized at much higher concentrations.
The Formula
Formulation
Stability
Demonstrates moderate thermal stability due to its heat-treated extraction process (80°C); ideally stabilized in aqueous phases using Phosphate-Buffered Saline (PBS).
Synergies
- Niacinamide
- Vitamin C
- Hyaluronic Acid
- Peptides
Safety
Safety Profile
Classified as a non-irritating botanical extract with zero adverse effects reported during high-concentration clinical testing.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A high-performance biotech botanical that offers a rare dual benefit of significant melanin suppression and structural anti-aging support.
Related
Similar Ingredients
Finding similar ingredients…
References
Sources