Science
Mechanism of Action
This filtrate operates via a four-fold molecular pathway: it upregulates mRNA expression of HAS1, FLG, and AQP3 to enhance deep-tissue hydration; inhibits tyrosinase enzymes to modulate melanin production; protects the extracellular matrix by inhibiting elastase and neutralizing reactive oxygen species (ROS); and reinforces the skin barrier by increasing the synthesis of structural proteins like Claudin 1 and Involucrin.
Research
Clinical Evidence
High confidence1.25%
Key findings
- 01 Demonstrated a significant 25.05% reduction in transepidermal water loss (TEWL) after only 10 minutes of topical application.
- 02 A concentration of 1.25% was shown to maximally boost water content in keratinocytes, with higher concentrations yielding diminishing returns for hydration.
- 03 An 8-week clinical assessment showed measurable reductions in periorbital wrinkle area and length, alongside improvements in skin smoothness.
Transparency
Dusting Analysis
Because fermentation filtrates are often marketed as primary active ingredients, 'dusting' is rare but possible in mass-market products where they appear at the very bottom of the INCI list. At Moumoujus, we note that efficacy for hydration begins at 1.25%, making anything below 1% insufficient for clinical results.
The Formula
Formulation
Stability
The filtrate is thermally stable up to 50°C and maintains integrity at room temperature. It is compatible with both aqueous serums and lipid-based emulsions, though light-protective packaging is recommended to preserve sensitive vitamin content.
Synergies
- Niacinamide
- Hyaluronic Acid
- Panthenol
- Peptides
Conflicts
- Strong oxidizers
- Extreme pH environments below 3.0 or above 8.0
- High-heat sterilization processes exceeding 80°C
Safety
Safety Profile
Generally Recognized as Safe (GRAS) by the FDA. Formulations must ensure the raw material is verified free from fungal aflatoxins.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A highly versatile, low-irritancy powerhouse that provides scientifically-backed improvements to hydration, barrier function, and skin tone.
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References
Sources