Science
Mechanism of Action
This extract operates on a cellular level by activating the SIRT1 (longevity) signaling pathway, which enhances the skin's natural repair mechanisms. It preserves the extracellular matrix by upregulating TIMP-1 to inhibit collagen-degrading enzymes (MMPs) and provides robust antioxidant defense by neutralizing UV-induced reactive oxygen species.
Research
Clinical Evidence
High confidence2.5%
Key findings
- 01 In vivo testing demonstrated that a 2.5% topical application resulted in a 38% improvement in collagen density and a 27% reduction in abnormal skin thickening caused by UV exposure.
- 02 In vitro analysis at 100 µg/mL confirmed the total inhibition of UVB-induced ROS and the significant suppression of MMP-1 and MMP-13 enzymes without cellular toxicity.
Transparency
Dusting Analysis
While biologically active at very low concentrations (0.01%) in vitro, the significant structural improvements in collagen density seen in vivo were achieved at 2.5%. Formulations using this ingredient at 'label-only' concentrations below 0.1% likely miss the significant anti-aging benefits.
The Formula
Formulation
Stability
To preserve the integrity of the fermented bioactive peptides, this extract is heat-sensitive and must be incorporated during the cooling phase of production (below 40°C).
Synergies
- Niacinamide
- Hyaluronic Acid
- Squalane
Conflicts
- Strong oxidizing agents
- High pH environments (>8.0)
- Highly acidic environments (<3.5)
Safety
Safety Profile
Listed as safe in the EU Cosmile database; independent assays confirm a lack of cytotoxicity and skin irritation at active levels.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A potent, fermentation-derived powerhouse that offers scientifically-backed protection against collagen degradation and cellular aging.
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References
Sources