Science
Mechanism of Action
This multi-component ingredient leverages a fermentation process to enhance the bioavailability and efficacy of its constituents. Fermented rice, particularly when influenced by Aspergillus oryzae, delivers a rich array of amino acids, organic acids, peptides, polyphenols, and vitamins. These compounds collectively stimulate collagen synthesis, provide potent antioxidant defense against reactive oxygen species, reinforce the skin barrier, and contribute to both moisturizing and brightening effects, with potential roles in sebum regulation and melanogenesis inhibition. Calendula Officinalis Flower adds to the anti-aging profile by influencing glycoprotein and collagen metabolism, promoting re-epithelialization and accelerated healing. It also exhibits antimicrobial, moisturizing (via mucilage and saponins), antioxidant, and soothing properties beneficial for irritated and sensitive skin. Ocimum Tenuiflorum (Holy Basil) contributes general anti-inflammatory, antioxidant, and antimicrobial actions, although specific mechanistic data for its fermented leaf filtrate on skin were not detailed in the provided research.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 In vitro investigations demonstrated that red rice fermented by Aspergillus oryzae (RRFA) provided anti-aging, antioxidant, moisturizing, repairing, and whitening benefits. It promoted human dermal fibroblast cell proliferation, enhanced mRNA expression of ECM-related anti-aging genes, reduced reactive oxygen species production, and boosted Aquaporin 3, Filaggrin, and Hyaluronan Synthase 1 mRNA expression, leading to elevated moisture levels in a 3D epidermal model.
- 02 An 8-week clinical study involving a face cream containing Yeast/Rice Fermentation Filtrate (RFF) showed significant reductions in wrinkle area and length around the eyes, alongside improvements in skin firmness and smoothness.
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
The specific complex ingredient 'ASPERGILLUS/CALENDULA OFFICINALIS FLOWER/HYDROLYZED RICE/OCIMUM TENUIFLORUM LEAF FERMENT FILTRATE' has not undergone individual review by the Cosmetic Ingredient Review (CIR) Expert Panel or SCCS, and no specific FDA status was found. However, individual components have partial assessments. The CIR Expert Panel concluded that *Calendula officinalis extract and related ingredients* are safe for cosmetic use, demonstrating non-genotoxicity, non-irritation, non-sensitization, and non-photosensitization in animal and clinical tests, though mild ocular irritation was noted. For *Aspergillus/Rice Ferment Filtrate*, EWG Skin Deep indicates low concerns regarding cancer, allergies, immunotoxicity, and developmental/reproductive toxicity, despite limited data availability.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This ingredient complex is valuable for its multifaceted skincare benefits, combining anti-aging, hydration, and soothing properties derived from its fermented rice, calendula, and holy basil components.
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References
Sources