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Moumoujus

ASPERGILLUS/ANGELICA TENUISSIMA ROOT FERMENT EXTRACT.

Valuable / HUMECTANT, SKIN CONDITIONING, SKIN PROTECTING

ASPERGILLUS/ANGELICA TENUISSIMA ROOT FERMENT EXTRACT is a sophisticated fermented botanical extract engineered to comprehensively address signs of photoaging, fortify the skin's natural barrier, and deliver robust hydration. It demonstrates significant capacity to modulate inflammatory responses, making it highly suitable for promoting skin resilience and comfort.

Summary

Skin-Conditioning Agent Humectant Skin Protecting

Science

Mechanism of Action

This ferment exerts its action through multi-faceted cellular pathways. It effectively improves the integrity of the extracellular matrix by promoting procollagen type-1 synthesis and secretion, while concurrently suppressing the expression of matrix metalloproteinase-1 (MMP-1) and elastase, crucial for its anti-photoaging and anti-wrinkle effects. Inflammatory attenuation is achieved by upregulating photo-protective hemeoxygenase-1 and inhibiting pro-inflammatory cyclooxygenase-2. Additionally, it enhances skin barrier function and water retention by boosting the expression of key barrier components, including filaggrin, involucrin, loricurin, and SPTLC1, and further mitigates inflammation by reducing inflammatory chemokines (TARC) and suppressing pro-inflammatory cytokines (IL-6, TNF-α) and nitric oxide production.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 In vitro studies using human keratinocyte (HaCaT) and human foreskin fibroblast (Hs68) skin cells evidenced its anti-photoaging potential through improved extracellular matrix integrity, enhanced procollagen type-1 synthesis and secretion, and suppression of MMP-1 and elastase expression. These studies also noted its ability to attenuate inflammatory responses.
  2. 02 Further in vitro research in HaCaT cells demonstrated upregulation of essential skin barrier components (filaggrin, involucrin, loricurin, SPTLC1) and inhibition of the inflammatory chemokine TARC. In LPS-induced RAW264.7 cells, it suppressed pro-inflammatory cytokines (IL-6, TNF-α) and nitric oxide, indicating significant anti-atopic, barrier-strengthening, and moisturizing capabilities.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) has not conducted a specific safety assessment for ASPERGILLUS/ANGELICA TENUISSIMA ROOT FERMENT EXTRACT. General CIR assessments for other yeast-derived ingredients do not directly apply to this unique fermented extract, and its FDA regulatory status remains undefined.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

This ferment presents as a valuable, multi-functional ingredient due to its demonstrated efficacy in anti-photoaging, barrier enhancement, and anti-inflammatory mechanisms, despite the current absence of specified topical application concentrations and CIR review.

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