Science
Mechanism of Action
This extract operates by activating the extracellular signal-regulated kinase 1/2 (ERK1/2) pathway, directly leading to enhanced keratinocyte proliferation. It also up-regulates the mRNA expression of key factors such as c-fos, c-jun, and vascular endothelial growth factor (VEGF), contributing to its reparative and calming effects on the skin.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Demonstrated a 131.15% increase in keratinocyte proliferation in HaCaT cells and a 216.94% improvement in in vitro wound closure via re-epithelialization. An in vivo murine assay showed a 22.13% increase in wound closure by day 5.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Bioactive compounds, including saponins, are primarily water-soluble. For optimal preservation of beneficial compounds, incorporation during the cool-down phase (below 40–50°C / 104–122°F) is recommended. The emulsifying and foaming activities of its saponins are sensitive to variations in pH, salt, and sucrose concentrations.
Safety
Safety Profile
Specific topical safety assessments (CIR, SCCS, FDA) for Asparagus Lucidus Root Extract are currently unavailable. While Asparagus officinalis holds 'generally recognized as safe' (GRAS) status for food, documented cases of allergic reactions, including allergic contact dermatitis, exist for that species. However, overall irritancy for Asparagus Lucidus Root Extract is assessed as low.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Asparagus Lucidus Root Extract is a valuable ingredient for promoting skin regeneration and soothing irritated skin, with scientifically demonstrated efficacy in wound healing and keratinocyte proliferation.
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References
Sources