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Moumoujus

ASIATICOSIDE.

Valuable CAS 16830-15-2 / ANTIOXIDANT, PERFUMING, SKIN CONDITIONING

Asiaticoside, a purified triterpenoid from Centella asiatica, is a potent ingredient known for its remarkable ability to stimulate skin regeneration and repair. It enhances collagen synthesis, accelerates wound healing, and provides significant anti-inflammatory and antioxidant protection, making it ideal for maintaining skin resilience and health.

Summary

antioxidant skin conditioning anti-inflammatory collagen booster wound healing scar prevention barrier repair moisturizing

Science

Mechanism of Action

This active compound strengthens the skin by promoting the synthesis of Type I collagen within human dermal fibroblast cells, operating via Smad signaling pathways. It also fosters the growth of new blood vessels through VEGF stimulation, which is vital for tissue repair and wound contraction. Asiaticoside additionally functions as a potent anti-inflammatory and antioxidant, calming redness and neutralizing free radicals. Furthermore, it aids in restoring the skin barrier and boosting hydration by encouraging hyaluronic acid production, and can modulate fibroblast activity to reduce scar formation.

Research

Clinical Evidence

High confidence
Effective range 0.2–5%
Optimal

N/A

Key findings

  1. 01 Demonstrated safety and good tolerability in topical concentrations ranging from 0.2% to 5%.
  2. 02 Shown to elevate antioxidant levels in rat skin at a 0.2% concentration.
  3. 03 Facilitated burn wound healing in mice via local application (10 pg, 1 ng, or 100 ng/wound area), by modulating cytokine levels, stimulating angiogenesis, and promoting epithelial cell proliferation.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH ≤8.1
0 7 14

Stability

Asiaticoside maintains stability across acidic and neutral pH conditions but begins to decompose under basic conditions, particularly at pH levels around 8.2 and higher. It is soluble in organic solvents such as ethanol and DMSO, and can also be formulated into aqueous solutions (e.g., PBS pH 7.2) at approximately 10 mg/ml, enabling solvent-free preparations.

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
5%
Sensitization risk Low

Generally considered safe and well-tolerated within a 0.2% to 5% concentration range, with a low allergenic potential. It complies with European Union cosmetic regulations. While side effects are minimal, rare instances of mild allergic reactions to Centella asiatica (which contains asiaticoside) have been reported in highly sensitive individuals, hence patch testing is recommended for very reactive or allergy-prone skin types.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Asiaticoside is a valuable ingredient for promoting comprehensive skin health, offering significant regenerative, protective, and soothing benefits across a wide range of skin concerns and types.

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