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ASCORBYL SUCCINOYL TETRAPEPTIDE-21.

Valuable / ANTIOXIDANT, SKIN CONDITIONING

ASCORBYL SUCCINOYL TETRAPEPTIDE-21 is an advanced ingredient featuring a signal peptide, Tetrapeptide-21, expertly conjugated with an ascorbic acid derivative via a succinyl chain. This dual-action component is engineered to rejuvenate skin by promoting the synthesis of essential structural proteins and delivering powerful antioxidant protection.

Summary

Skin-identical ingredient Antioxidant Anti-aging Collagen Synthesis Support Skin Firming & Elasticity Wrinkle Reduction Extracellular Matrix Support Skin Conditioning

Science

Mechanism of Action

This ingredient functions through a synergistic mechanism. Its Tetrapeptide-21 component acts as a signal peptide, mimicking natural skin-protein breakdown signals to prompt the dermis to produce new collagen, hyaluronic acid, and fibronectin. This stimulation of the extracellular matrix leads to enhanced skin firmness, elasticity, and a visible reduction in wrinkle depth. Additionally, it may contribute to preserving skin integrity by potentially inhibiting matrix metalloproteinases (MMPs), enzymes that degrade collagen and elastin. The conjugated ascorbyl (Vitamin C) derivative provides significant antioxidant benefits, protecting skin from environmental stressors, and further supports collagen synthesis, aiding in improved skin density, elasticity, and accelerated wound healing.

Research

Clinical Evidence

High confidence
Effective range 0.5–5%
Optimal

0.5%

Key findings

  1. 01 An 8-week in-vivo study involving 60 volunteers demonstrated significant improvement in skin volume, roughness, and elasticity, outperforming Matrixyl.
  2. 02 In the same 60-volunteer in-vivo study, this concentration also led to enhanced skin volume, roughness, and elasticity over 8 weeks, exceeding Matrixyl's performance.
  3. 03 A separate anti-wrinkle study with 60 participants observed visible reduction in wrinkles around the eye area.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Unknown
Optimal pH N/A
0 7 14

Stability

For optimal shelf-life, formulations containing Tetrapeptide-21 are recommended for refrigeration prior to use in a properly preserved cosmetic base. The succinyl chain linking the peptide to ascorbic acid is shown to enhance the conjugate's stability against proteolytic degradation.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

While ASCORBYL SUCCINOYL TETRAPEPTIDE-21 itself lacks direct safety assessments by the CIR, SCCS, or FDA, its individual precursor components, such as various ascorbic acid derivatives and peptides, have undergone comprehensive safety reviews.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

This innovative ingredient, combining a signal peptide with Vitamin C, offers significant anti-aging benefits by stimulating skin's structural proteins and providing antioxidant protection, making it a valuable addition to advanced skincare formulations.

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