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Moumoujus

ARUNCUS DIOICUS LEAF/STEM EXTRACT.

Valuable / SKIN PROTECTING

Aruncus Dioicus Leaf/Stem Extract is a botanical active, originating from Ulleung-do, South Korea, recognized for its precision in mitigating signs of skin aging and inflammation. It targets cellular pathways to reduce UV-B induced damage and soothe irritated skin, offering a multi-functional approach to skin health.

Summary

Antioxidant Anti-inflammatory Anti-aging

Science

Mechanism of Action

This extract operates through several key pathways: it significantly downregulates matrix metalloproteinases (MMP1, 2, 3) and transcription factors p-p38 and c-fos, crucial components in UV-B induced photoaging. As an anti-inflammatory agent, it modulates Akt/mTOR and JAK2/STAT3 signaling, suppresses keratinocyte hyperproliferation, and inhibits immune cell infiltration, effectively reducing markers associated with inflammation. Its antioxidant capacity further protects the skin from radical damage.

Research

Clinical Evidence

Medium confidence
Effective range 5–50%
Optimal

N/A

Key findings

  1. 01 In vitro studies on human skin fibroblast cells (CCD-986sk) demonstrated a notable reduction in mRNA transcripts and total proteins for MMP1, 2, and 3, alongside decreased p-p38 and c-fos, indicating significant anti-aging potential by mitigating UV-B-induced damage.
  2. 02 In murine models treated with the extract, a substantial attenuation of psoriasis-like skin inflammation was observed, characterized by suppression of keratinocyte hyperproliferation, reduced immune cell infiltration, and downregulation of psoriatic markers. It also suppressed Akt/mTOR and JAK2/STAT3 signaling in HaCaT cells.
  3. 03 An ethanol extract showed superior antioxidant and anti-wrinkling effects compared to a water extract, suggesting potent skin tensor benefits.

Transparency

Dusting Analysis

Not commonly dusted

There is no information to suggest this ingredient is commonly 'dusted' or used below an effective concentration threshold.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

An ethanol extract demonstrated better antioxidant and anti-wrinkling effects than a water extract, suggesting effective solubility in both polar and moderately polar solvents. Specific optimal pH ranges for stability have not been identified.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Currently not reviewed by major regulatory bodies such as CIR, SCCS, or FDA. Industry sources indicate it is a 'New ingredient' with ongoing research into its safety profile.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

This ingredient presents as a valuable multi-functional active, demonstrating robust anti-aging, anti-inflammatory, and antioxidant properties in in vitro and preclinical studies, positioning it as a promising candidate for precision skincare formulations pending further human clinical data.

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