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Moumoujus

ARTOCARPUS LAKOOCHA WOOD EXTRACT.

Valuable CAS - / ANTIMICROBIAL, ANTIOXIDANT, BLEACHING, SKIN CONDITIONING

Artocarpus Lakoocha Wood Extract, derived from the tropical fruit tree, is a multi-functional active ingredient primarily recognized for its potent skin brightening properties. Rich in oxyresveratrol, it precisely targets melanin synthesis while also offering significant antioxidant, anti-inflammatory, and antimicrobial benefits for comprehensive skin health.

Summary

Antimicrobial Antioxidant Bleaching Skin conditioning Anti-inflammatory Anti-acne Anti-glycation

Science

Mechanism of Action

This extract primarily functions through oxyresveratrol, a potent tyrosinase inhibitor, which effectively reduces melanin synthesis to brighten skin. Its robust antioxidant activity scavenges free radicals, mitigating oxidative stress. Furthermore, it exerts anti-inflammatory effects by downregulating pro-inflammatory mediators such as IL-6, TNF-alpha, NF-kB, and COX-2, while simultaneously upregulating trefoil factor 2. Antimicrobial action against bacteria like Cutibacterium acnes addresses acne concerns, and its anti-glycation properties contribute to overall skin integrity.

Research

Clinical Evidence

High confidence
Effective range 0.1–0.25%
Optimal

N/A

Key findings

  1. 01 Clinical application to the upper arm resulted in a significant reduction in melanin content within 4 weeks, with maximum skin brightening observed at week 12. No adverse effects were reported.
  2. 02 Daily use of a 0.1% w/w lotion demonstrated significant skin brightening on the upper arms after 2 weeks and on facial cheeks after 3 weeks.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH 3 – 8
0 7 14

Stability

Oxyresveratrol demonstrates optimal stability within a pH range of 3.0 to 8.0. For formulations containing Artocarpus Lakoocha Wood Extract, a narrower pH range of 4.0-6.0 is specifically recommended to ensure maximum stability. To further enhance stability, the inclusion of 0.1% Sodium Metabisulphite and 0.2% Disodium EDTA, alongside other antioxidants, is advised. Products should be protected from light, stored refrigerated (5-10°C), and exposed to heat above 60°C must be avoided.

Synergies

  • Sodium Metabisulphite
  • Disodium EDTA
  • Other antioxidants

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Oxyresveratrol, the primary active compound, appears safe for topical use, with animal studies showing no irritation, edema, or erythema. Human clinical studies utilizing 0.1% and 0.25% concentrations reported no adverse effects. While higher concentrations (IC50 of 6.08 ± 1.28 mg/ml) demonstrated moderate cytotoxicity in human skin fibroblasts, anti-inflammatory benefits were observed at non-cytotoxic concentrations (0.07–0.31 mg/ml). No GHS classification information was found by The Good Scents Company.

Your Skin

Skin Compatibility

Yes Normal
No Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Artocarpus Lakoocha Wood Extract is a valuable, multi-targeted ingredient for precision skincare formulations, offering clinically supported brightening, robust antioxidant and anti-inflammatory benefits, and low irritancy at effective concentrations.

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