ARTOCARPUS ALTILIS WOOD EXTRACT.

This extract confers its benefits by several distinct mechanisms. It acts as a photoprotective agent, mitigating structural damage induced by UVB radiation through the suppression of matrix metalloproteinase-1 (MMP-1) production in fibroblasts and a reduction in pro-inflammatory cytokines, TNF-α and IL-6, in keratinocytes. Its antioxidant activity is achieved by efficiently scavenging free radicals and diminishing oxidative stress. The extract exhibits anti-inflammatory properties, with its flavonoid content inhibiting key inflammatory mediators like 5-lipoxygenase and reducing the secretion of TNF-α and IL-1β. Furthermore, it promotes skin brightening by activating the MAPK signaling pathway, leading to the degradation of microphthalmia-associated transcription factor (MITF) and a subsequent decrease in tyrosinase synthesis and melanin production. Lastly, it aids in anti-aging by neutralizing free radicals and functions as a humectant to increase skin moisture content.