Science
Mechanism of Action
This extract operates via a dual-action pathway: it suppresses pro-inflammatory cytokines like IL-6 and TNF-α by inhibiting the NF-κB pathway while simultaneously upregulating the Nrf2/HO-1 signaling route to bolster the skin's internal antioxidant defenses. It further modulates tone by interfering with tyrosinase activity to prevent melanin overproduction.
Research
Clinical Evidence
Medium confidence2.5%
Key findings
- 01 In vitro models demonstrate that a concentration of 60 μg/mL can reduce IL-6 expression by 82.04% and TNF-α by 67.38%.
- 02 Patent data (KR101835739B1) identifies efficacy across a broad range for the treatment of acne-induced inflammation and hyperpigmentation.
Transparency
Dusting Analysis
Due to its potent botanical reputation, it is frequently included in formulations at negligible concentrations (below 0.1%) for marketing purposes. To achieve the physiological anti-inflammatory and brightening effects noted in research, a concentration of at least 1-3% is typically required.
The Formula
Formulation
Stability
Highly sensitive to thermal degradation and UV exposure. Should be incorporated during the cool-down phase (below 40°C) and stored in opaque, airtight packaging to preserve chlorogenic acid integrity.
Synergies
- Centella Asiatica
- Niacinamide
- L-Ascorbic Acid
Conflicts
- Strong oxidizing agents
- Extremely low pH formulations (<4.0)
Safety
Safety Profile
Recognized as a safe edible herb in East Asia; topical application shows high biocompatibility with no significant reports of sensitization in standard botanical assessments.
Your Skin
Skin Compatibility
Our Assessment
Verdict
An exceptional multi-tasking botanical for sensitive and acne-prone skin, provided it is formulated at therapeutic levels rather than label-claim percentages.
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