Science
Mechanism of Action
This extract functions by suppressing the pathways responsible for inflammatory stress, specifically inhibiting pro-inflammatory cytokines such as IL-6 and TNF-alpha. Its rich flavonoid profile neutralizes free radicals via DPPH and ABTS scavenging, while its natural chemical constituents disrupt the integrity of bacterial cell membranes to manage blemish-prone environments.
Research
Clinical Evidence
Medium confidence1%
Key findings
- 01 Observed significant reduction in acne and eczema symptoms over a 14-day local application period at 1% concentration.
- 02 Demonstrated Minimum Inhibitory Concentration (MIC) against Staphylococcus strains (MRSA/MRSE) at levels between 0.21% and 0.28%.
Transparency
Dusting Analysis
Because botanical extracts are often marketed for 'storytelling,' many formulations include this at negligible levels (below 0.1%). To achieve the documented antimicrobial and anti-inflammatory benefits seen in 2023-2025 research, a minimum concentration of 0.2% is required.
The Formula
Formulation
Stability
Highly susceptible to degradation via oxidation and UV exposure; requires opaque, airtight packaging. Sensitive to thermal stress which may trigger polymerization of phenolic components.
Synergies
- Niacinamide
- Centella Asiatica
- Ceramides
Conflicts
- Strong oxidizing agents
- Metal ions
- Strong mineral acids
Safety
Safety Profile
Contains thujone (alpha and beta), which is subject to strict regulatory limits due to potential neurotoxicity. While safe in topical cosmetic applications within recommended limits, it is typically restricted in fragrance concentrates to under 0.8%.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A potent, multifunctional botanical for managing inflammatory skin conditions and microbial balance, provided it is stabilized and dosed correctly.
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References
Sources