Science
Mechanism of Action
This extract operates through precision epigenetic regulation, modulating miR-486-5p to suppress HYBID (Hyaluronan Binding Protein Involved in HA Depolymerization), which prevents the degradation of high-molecular-weight hyaluronic acid. Additionally, it inhibits melanogenesis by downregulating TRP-1 translational levels and provides anti-inflammatory relief by suppressing the synthesis of nitric oxide and histamine.
Research
Clinical Evidence
High confidence0.5%
Key findings
- 01 Demonstrated significant protection against blue light-induced cellular carbonylation and oxidation in human skin explants at 0.1%.
- 02 Observed suppression of HYBID expression in fibroblasts, effectively maintaining HA levels at concentrations between 0.1% and 1.0%.
- 03 A concentration of 1.25 ppm was sufficient to increase cell proliferation by 18.7% and inhibit melanin synthesis via TRP-1 downregulation.
Transparency
Dusting Analysis
Because clinical efficacy for blue light protection and HA preservation begins at 0.1%, inclusion levels below this threshold are likely for marketing claims ('label dusting') rather than functional performance.
The Formula
Formulation
Stability
The extract contains photo-labile polyphenols such as chlorogenic acid; it requires protection from UV light and high-temperature processing to remain active.
Synergies
- Hyaluronic Acid
- Niacinamide
- Vitamin C
Conflicts
- Strongly alkaline environments
- High heat
- Prolonged UV exposure
Safety
Safety Profile
Recognized as safe in food contexts (GRAS) and listed in IECIC. If essential oil fractions are present, testing for trace allergens like linalool is recommended.
Your Skin
Skin Compatibility
Our Assessment
Verdict
An exceptional precision ingredient for urban environments, offering scientifically-backed protection against digital aging and internal moisture loss.
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References
Sources