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Moumoujus

ARTEMISIA CAPILLARIS EXTRACT.

Valuable

A sophisticated botanical bioactive derived from Capillary Wormwood, valued for its dual-action ability to neutralize inflammatory triggers while protecting the skin's structural integrity. It serves as a precision tool for both calming reactive complexions and maintaining long-term hydration through advanced enzymatic regulation.

Summary

skin conditioning soothing antioxidant antimicrobial hyaluronic acid protection

Science

Mechanism of Action

This extract operates via a multi-pathway molecular approach: it inhibits Nitric Oxide (NO) and histamine release to soothe irritation, while simultaneously suppressing the HYBID (KIAA1199) enzyme to prevent the degradation of endogenous hyaluronic acid. Furthermore, it modulates pigmentation by downregulating tyrosinase-related protein 1 (TRP-1) and provides antioxidant defense through its natural coumarin and capillene content.

Research

Clinical Evidence

High confidence
Effective range 0.0005–3%
Optimal

1.5%

Key findings

  1. 01 Concentrations of 0.5% to 1.0% significantly suppress HYBID expression and upregulate miR-486-5p, effectively preventing extrinsic aging by shielding hyaluronic acid from enzymatic breakdown.
  2. 02 At 1.5% to 3.0% in topical formulations, the extract demonstrates a measurable reduction in skin thickness, erythema, and scaling in inflammatory models.
  3. 03 As low as 5 ppm (0.0005%) shows high anti-melanogenic activity by inhibiting melanin synthesis and TRP-1 protein expression.

Transparency

Dusting Analysis

Commonly dusted
Min. effective
0.5%
Red flag below
0.05%

Due to its efficacy at ultra-low concentrations (5 ppm) for brightening, brands often 'dust' this ingredient at symbolic levels. However, to achieve its clinically validated anti-inflammatory and anti-aging benefits, a minimum threshold of 0.5% to 1.5% is required.

The Formula

Formulation

Solubility
Water
Optimal pH 5 – 7
0 7 14

Stability

The extract is thermolabile and should not be exposed to temperatures exceeding 50°C. It is also highly sensitive to UV light, which can degrade its bioactive coumarins, necessitating UV-protective or opaque packaging.

Synergies

  • Hyaluronic Acid
  • Niacinamide
  • Centella Asiatica

Conflicts

  • High heat
  • Strong oxidizing agents
  • Direct UV exposure

Safety

Safety Profile

CIR Status
Insufficient data
Max tested
3%
Pregnancy
Safe
Sensitization risk Low

Contains trace natural allergens such as Linalool. Formulations intended for compromised or eczematous skin should ensure Linalool concentrations remain below 10 ppm.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

An exceptional multi-tasking botanical that offers scientifically-backed benefits for redness reduction and hyaluronic acid preservation when utilized at honest, therapeutic percentages.

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