Science
Mechanism of Action
It acts as a molecular switch to deactivate the MAPK signaling pathway, effectively dampening the production of pro-inflammatory cytokines like IL-6 and IL-8. Simultaneously, it triggers the mRNA expression of essential structural proteins, including filaggrin and loricrin, to physically rebuild the skin's protective shield.
Research
Clinical Evidence
High confidence2%
Key findings
- 01 Demonstrated a 63.9% increase in hydration and a 21.5% reduction in TEWL over 4 weeks at 1-2% concentration.
- 02 Shown to restore critical barrier proteins (filaggrin, loricrin, desmoglein-1) in 3D epidermal models at 1% concentration.
Transparency
Dusting Analysis
Many 'soothing' products include this extract at symbolic levels (<0.1%) for marketing claims. Clinical data confirms that a minimum of 1% is required to achieve measurable barrier repair and anti-inflammatory results.
The Formula
Formulation
Stability
Heat-sensitive phytocompound; must be integrated during the cool-down phase at temperatures below 40°C to maintain bioactivity.
Synergies
- Ceramides
- Panthenol
- Glycerin
Conflicts
- Strong oxidizing agents
- Extreme pH environments (<3.5 or >8.0)
Safety
Safety Profile
While a formal CIR assessment is pending, it is authorized under EU CosIng standards and has a documented history of safety in commercial skincare up to 4%.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A highly effective, scientifically-backed botanical for repairing sensitive barriers and suppressing cellular inflammation when used at therapeutic doses.
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