ARGININE PORPHYRA YEZOENSIS EXTRACT.

Key findings

1. 01 Studies on human keratinocytes (HaCaT cells) demonstrate that Porphyra yezoensis extract, at concentrations from 10 to 50 μg/mL, significantly reduces Urban Particulate Matter (UPM)-induced XRE promoter activity and Reactive Oxygen Species (ROS) production, showcasing potent anti-pollutant and antioxidant capabilities.
2. 02 Porphyra 334, an active compound isolated from the extract, attenuated cellular ROS levels, inhibited AhR nuclear translocation, and decreased CYP1A1 expression and mRNA levels at concentrations between 1 and 100 μM, offering protection against UPM-induced damage and promoting cell proliferation.
3. 03 An 80% methanol extract of Porphyra yezoensis modulated Ultraviolet B (UVB)-induced cell death in human keratinocytes, influencing cell viability and apoptosis through the activation of c-Jun N-terminal kinase (JNK) and extracellular signal–regulated kinase (ERK) signaling pathways, and by modulating redox status and glutathione content.

Stability

Porphyran, a significant polysaccharide component derived from Porphyra species, is reported to undergo decomposition at temperatures exceeding 60 °C and outside the pH range of 3.0–12.0. The stability of any protein components within the extract can also be influenced by pH and the concentration of arginine.

Synergies

• Arginine may form complexes with Alpha Hydroxy Acids (AHAs), facilitating a 'time-release' effect that can reduce irritation while maintaining exfoliation efficacy.