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ARGININE HEXYLDECYL PHOSPHATE.

Insufficient Data CAS 111129-35-2 / CLEANSING, SKIN CONDITIONING - EMOLLIENT, SURFACTANT - CLEANSING

Arginine Hexyldecyl Phosphate is a unique skin-conditioning agent that merges the hydrating and barrier-supporting benefits of L-Arginine with a lipophilic phosphate component, designed to soften and smooth the skin. This derivative also functions as an emollient and surfactant, contributing to both skin texture and cleansing properties.

Summary

Emollient Skin-Conditioning Agent Cleansing Agent Surfactant

Science

Mechanism of Action

This compound leverages L-Arginine, a vital natural moisturizing factor (NMF), to significantly boost skin hydration and reinforce barrier integrity through its cationic charge. L-Arginine additionally promotes collagen synthesis, aids in epidermal repair, and offers soothing benefits. The integration of a lipophilic phosphate derivative means Arginine Hexyldecyl Phosphate also functions as an effective emollient, imparting a softer, smoother skin texture. Its surfactant properties allow for gentle cleansing, while the inherent electrostatic interactions between arginine's guanidinium group and phosphate components are fundamental to its action.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Aqueous solutions of the L-Arginine component are notably alkaline and prone to absorbing atmospheric carbon dioxide over time; storage in a buffered, sealed container for less than one month is recommended to maintain integrity. Furthermore, similar arginine esters have demonstrated susceptibility to degradation by lipase enzymes at a pH of 6.8, suggesting potential enzymatic instability.

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Low

While the Cosmetic Ingredient Review (CIR) Expert Panel has affirmed the safety of α-amino acids, including Arginine (with a maximum use concentration range of 2.0 x 10-5% to 18%), and L-Arginine is recognized as 'Generally Recognized as Safe (GRAS)' by the FDA, specific CIR data for Arginine Hexyldecyl Phosphate are currently insufficient. No GHS hazard statements have been identified for this particular derivative. Arginine itself is broadly well-tolerated topically, even by individuals with sensitive skin, and typically presents no reported side effects.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

Arginine Hexyldecyl Phosphate offers promising benefits as a hydrator, barrier enhancer, and emollient by leveraging L-Arginine's properties, but its specific safety and efficacy profile as a derivative warrants further dedicated research.

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