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Moumoujus

ARENARIA SERPYLLIFOLIA LEAF EXTRACT.

Insufficient Data / SKIN CONDITIONING

Arenaria Serpyllifolia Leaf Extract, derived from Thyme-leaved Sandwort, demonstrates notable antioxidant capabilities and exhibits significant antimicrobial and antibiofilm activities in laboratory settings. Its rich phytochemical composition contributes to these multifaceted effects, suggesting potential for comprehensive skin protection and microbial balance.

Summary

Antioxidant Antimicrobial Anti-biofilm Metal Chelator

Science

Mechanism of Action

This extract functions as a potent scavenger of free radicals and an effective metal ion chelator, which collectively underpin its antioxidant properties. Its antimicrobial and antibiofilm actions primarily involve disrupting bacterial quorum sensing mechanisms, crucial for bacterial communication and virulence. The presence of diverse phytochemicals, including flavonoids like epicatechin and quercetin, phenols, and terpenoids, synergistically contributes to its biological activities.

Research

Clinical Evidence

Low confidence
Effective range 0.035554–0.53%
Optimal

N/A

Key findings

  1. 01 Exhibited strong antioxidant properties, measured by DPPH radical scavenging activity, with an IC50 of 0.035554% (355.54 ± 20.62 μg/mL).
  2. 02 Demonstrated iron chelating ability with an IC50 of 0.53% (5.30 ± 4.44 mg/mL).
  3. 03 Inhibited bacterial biofilm formation by 82.52 ± 2.2% at a Minimal Inhibitory Concentration (MIC) of 0.5% (5 mg/mL).
  4. 04 Inhibited bacterial biofilm formation by 81.32 ± 2.4% at a sub-MIC dose of 0.4% (4 mg/mL).
  5. 05 Reduced violacein production in C. violaceum CV12472 strain by 90.76 ± 0.3% at MIC (0.5%, 5 mg/mL).
  6. 06 Reduced violacein production in C. violaceum CV12472 strain by 91.60 ± 0.1% at a sub-MIC dose of 0.1% (1 mg/mL).

Transparency

Dusting Analysis

Not commonly dusted
Min. effective
0.035554%

While potent antioxidant activity is observed at a low concentration of 0.035554%, significant antibiofilm and antimicrobial effects require higher concentrations, ranging from 0.1% to 0.5%. Formulating for a full spectrum of benefits would necessitate concentrations above the antioxidant-only threshold, making the ingredient less prone to dusting if multiple efficacies are targeted.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Specific optimal pH range and detailed stability notes are currently unavailable. As a botanical extract, it is generally understood that it may be sensitive to degradation from environmental factors such as oxygen, light, temperature, and moisture.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

No specific safety assessments from major regulatory bodies such as CIR, SCCS, or FDA have been found for Arenaria Serpyllifolia Leaf Extract, indicating a lack of comprehensive dermatological safety data.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

Arenaria Serpyllifolia Leaf Extract demonstrates promising in vitro antioxidant, antimicrobial, and antibiofilm properties, suggesting potential benefits for managing oxidative stress and microbial imbalances in the skin; however, its in vivo efficacy and comprehensive safety profile require further investigation for precise dermatological applications.

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