Science
Mechanism of Action
This extract operates by inhibiting the generation of reactive oxygen species (ROS), thereby functioning as an antioxidant. Its anti-inflammatory action is evidenced by its capacity to reduce key proinflammatory mediators such as IL-6, IL-8, and PGE2, alongside suppressing TRPV-1 activity in keratinocytes. Furthermore, it contributes to anti-aging and photoprotection by downregulating matrix metalloproteinase-1 (MMP-1), an enzyme responsible for collagen degradation, and simultaneously promoting the synthesis of type-1 procollagen in dermal fibroblasts, thus preserving skin integrity.
Research
Clinical Evidence
Medium confidence0.01%
Key findings
- 01 At 0.01%, Aralia Elata Root Extract significantly inhibited UVB-induced inflammatory markers in human keratinocytes (HaCaT), reducing IL-6 production by 25.6%, IL-8 by 5.3%, and PGE2 by 70.2%. It also decreased MMP-1 elevation by 20.0% and TRPV-1 activity by 41.9%.
- 02 In human dermal fibroblasts (HDF) at 0.01%, the extract effectively inhibited MMP-1 elevation and enhanced type-1 procollagen synthesis, demonstrating photoprotective and anti-aging benefits.
- 03 In vitro, it exhibited strong antioxidant activity with an IC50 of 0.00251%.
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
Cytotoxicity studies indicate a favorable safety profile at tested concentrations, showing no significant toxicity to human umbilical vein endothelial cells (HUVECs) up to 0.05%, macrophages (RAW 264.7) up to 0.01%, and keratinocytes (HaCaT) up to 0.03%.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Aralia Elata Root Extract is a valuable ingredient, offering significant antioxidant, anti-inflammatory, and anti-aging benefits for comprehensive skin protection and health.
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References
Sources