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Moumoujus

ARALIA ELATA LEAF EXTRACT.

Valuable CAS - / SKIN CONDITIONING

Aralia Elata Leaf Extract is a multi-functional botanical ingredient recognized for its potent antioxidant, anti-inflammatory, and anti-aging properties. It actively protects skin from environmental aggressors, soothes irritation, and supports crucial collagen synthesis for enhanced dermal health and a more youthful appearance.

Summary

Antioxidant Anti-inflammatory Anti-aging Photoprotective Soothing Collagen Boosting

Science

Mechanism of Action

This extract functions as a robust antioxidant by effectively scavenging free radicals and inhibiting the production of reactive oxygen species within skin keratinocytes. Its anti-inflammatory capabilities stem from modulating key signaling pathways, including PI3K/Akt and MAPK, and suppressing the expression of adhesion molecules like VCAM-1 and ICAM-1. It also reduces pro-inflammatory mediators such as TRPV-1 and MMP-1, which are implicated in inflammatory skin responses. Furthermore, the extract promotes anti-aging effects by increasing type-1 procollagen synthesis in dermal fibroblasts and providing protection against UV-induced damage.

Research

Clinical Evidence

Medium confidence
Effective range 0.0005–0.1%
Optimal

0.1%

Key findings

  1. 01 Demonstrated significant anti-inflammatory properties in human umbilical vein endothelial cells (HUVECs). It substantially reduced adhesion molecules VCAM-1 and ICAM-1 levels and attenuated PI3K/Akt signaling in LPS-treated HUVECs, with no observed cytotoxicity.
  2. 02 Provided photoprotective and anti-aging benefits. In human keratinocytes (HaCaT), it inhibited UVB-induced IL-6, IL-8, and PGE2 production by 25.6%, 5.3%, and 70.2% respectively. It also inhibited MMP-1 elevation by 20.0% and TRPV-1 by 41.9%. In human dermal fibroblasts (HDF), this concentration inhibited MMP-1 elevation and enhanced type-1 procollagen synthesis.
  3. 03 Exhibited potent antioxidant activity, demonstrating 92.36% free radical scavenging activity.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

The Cosmetic Ingredient Review (CIR) has not yet assessed Aralia Elata Leaf Extract for topical cosmetic use. In vitro studies on human umbilical vein endothelial cells (HUVECs) indicated no cytotoxicity at concentrations up to 5 μg/mL. While oral toxicity data in rats suggested a low acute and sub-chronic toxicity profile at tested dosages, this information does not directly establish a maximum safe topical concentration or confirm lack of sensitization in human skin.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Aralia Elata Leaf Extract is a valuable, multi-functional ingredient demonstrating significant antioxidant, anti-inflammatory, and anti-aging benefits, making it suitable for a broad spectrum of skincare applications and skin types.

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