Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

ARALIA ELATA BRANCH/LEAF EXTRACT.

Valuable CAS - / SKIN CONDITIONING

Aralia Elata Branch/Leaf Extract is a potent botanical extract recognized for its significant antioxidant and anti-inflammatory properties. It actively works to protect the skin from environmental stressors, reduce signs of inflammation, and support skin's natural resilience against premature aging.

Summary

Skin conditioning Antioxidant Anti-inflammatory Photoprotective Anti-aging Collagen synthesis booster

Science

Mechanism of Action

This extract exhibits robust antioxidant activity, outperforming Vitamin C in DPPH radical scavenging and effectively inhibiting reactive oxygen species (ROS) production in skin keratinocytes. Its anti-inflammatory action is mediated by suppressing TRPV-1 and MMP-1 activities, which are associated with inflammatory responses, and by modulating the PI3K/Akt and MAPK signaling pathways. Furthermore, it enhances procollagen synthesis in dermal fibroblasts, contributing to anti-aging benefits and offering photoprotective effects against UV-induced damage. It also reduces the expression of VCAM-1 and ICAM-1, crucial adhesion molecules involved in leukocyte migration during inflammation.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 A 70% ethanol extract of Aralia elata leaves (LAE) demonstrated anti-inflammatory properties in human umbilical vein endothelial cells (HUVECs) by modulating PI3K/Akt and MAPK signaling pathways at concentrations of 2.5 μg/mL and 5 μg/mL. No cytotoxicity was observed in HUVECs at 5 μg/mL.
  2. 02 A 70% ethanol extract showed photoprotective capabilities in UVB-exposed human keratinocytes and dermal fibroblasts. It reduced proinflammatory mediators, TRPV-1, and MMP-1 production, while simultaneously elevating collagen synthesis.

Transparency

Dusting Analysis

Not commonly dusted

There is no information in the provided research data to suggest that this ingredient is commonly dusted or has specific dusting thresholds.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

No specific stability information or optimal pH range was provided in the research data.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Aralia Elata Branch/Leaf Extract has not been formally reviewed by regulatory bodies such as CIR, SCCS, or FDA. While it is generally considered non-irritating and has 'no known side effects' when used as an herbal supplement, in vitro studies have indicated cytotoxicity at concentrations of 10 μg/mL, suggesting a potential for adverse effects at higher concentrations. The risk of irritation may also increase when formulated with other known problematic ingredients.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Aralia Elata Branch/Leaf Extract is a valuable ingredient, demonstrating significant antioxidant, anti-inflammatory, and photoprotective benefits, making it suitable for enhancing resilience across various skin types and anti-aging formulations.

Related

Similar Ingredients

Finding similar ingredients…