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Moumoujus

ARALIA CORDATA EXTRACT.

Valuable CAS - / SKIN CONDITIONING

Aralia Cordata Extract is a botanical active prized for its multifaceted protective properties. It demonstrably acts as a potent anti-inflammatory and antioxidant agent, contributing to skin resilience against environmental stressors and supporting overall skin health. This extract is noted for its ability to shield the skin from various external influences.

Summary

Anti-inflammatory Antioxidant Skin protectant Soothing

Science

Mechanism of Action

Aralia Cordata Extract exerts its protective effects primarily by modulating inflammatory pathways and neutralizing oxidative stress. It inhibits key inflammatory signaling molecules suchs as NF-κB and MAPKs, reduces the production of pro-inflammatory mediators like COX-2 and PGE(2), and suppresses caspase-3 activity and histamine release. Concurrently, its rich composition of phenolic compounds, carotenoids, and anthocyanins enables it to scavenge free radicals and inhibit reactive oxygen species (ROS) generation, thereby mitigating oxidative damage to skin cells.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Methanol extracts of Aralia cordata exhibited anti-inflammatory effects through inhibition of NF-κB and MAPKs signaling in LPS-stimulated RAW264.7 cells.
  2. 02 A constituent, 7-oxosandaracopimaric acid, inhibited COX-1 by 22.82 ± 1.94% and COX-2 by 15.86 ± 1.35% at 10 mM.
  3. 03 The constituent 7-oxosandaracopimaric acid significantly inhibited compound 48/80-induced histamine release from rat mast cells at 3.0 mM.
  4. 04 In cultured rat cortical neurons, the extract at 5-20 µg/mL inhibited hydrogen peroxide (H2O2)-induced apoptotic neuronal death, elevation of intracellular calcium concentration, and generation of reactive oxygen species (ROS).

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Extracts are typically prepared using polar solvents such as methanol or aqueous ethanol, indicating good solubility and stability in such mediums.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

The Cosmetic Ingredient Review (CIR) has not evaluated Aralia Cordata Extract. While its root has a history of traditional use in Japan, Korea, and China without reported safety issues, an in vitro study observed cytotoxicity in cell lines with Aralia cordata root extracts. Furthermore, research on a related species, Aralia elata, indicated potential concentration-dependent toxicity, where cell viability significantly decreased at 10 μg/mL compared to 5 μg/mL on HUVECs.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Aralia Cordata Extract is a valuable botanical ingredient, offering significant anti-inflammatory and antioxidant benefits to support resilient and calm skin, despite the absence of specific human topical clinical efficacy data.

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