Science
Mechanism of Action
It functions as a concentrated flagellin protein extract that interrupts the neuro-inflammatory loop by blocking Substance P secretion. It simultaneously inhibits Protease-Activated Receptor-2 (PAR-2) to suppress itching sensations and activates Toll-Like Receptors (TLR2, TLR4, TLR5) to trigger the skin's innate immune defense while accelerating cellular repair via fibroblast proliferation.
Research
Clinical Evidence
High confidenceN/A
Key findings
- 01 In vitro application at 3 µg/mL demonstrated a 2,121.3% increase in human beta-defensin 2 (hBD-2) stimulation, significantly boosting natural antimicrobial defenses.
- 02 A 50% reduction in PAR-2 receptor stimulation was achieved at 100 µg/mL, providing measurable anti-pruritic and anti-inflammatory benefits.
- 03 Real-world data from 5,910 patients showed a 56% decrease in dryness and a 60% reduction in itch severity within 7 days of twice-daily use.
- 04 Ex vivo testing confirmed a 66% improvement in barrier protection and a 71% increase in collagen density when used alongside topical treatments.
Transparency
Dusting Analysis
Because this active is potent at the microgram level (µg/mL), effective concentrations in final formulations can appear lower than traditional actives. However, it is often used in proprietary complexes where its absence or extreme dilution would negate its neuro-soothing properties.
The Formula
Formulation
Stability
Produced via fermentation at neutral pH; requires pH stabilizers like Arginine to maintain physiological skin balance. It is a protein-based extract and must be protected from denaturation.
Synergies
- Topical Corticosteroids
- Arginine
- Tromethamine
- Ceramides
Conflicts
- High temperatures (>40°C)
- Strong oxidizing agents
Safety
Safety Profile
Derived from non-pathogenic, non-spore-forming bacteria. It is clinically recognized for use in eczema-prone and highly reactive skin types.
Your Skin
Skin Compatibility
Our Assessment
Verdict
An exceptional postbiotic for sensitive and compromised skin that provides measurable neuro-sensory relief and rapid barrier restoration.
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References
Sources