Science
Mechanism of Action
This ingredient functions by disrupting the neuro-inflammatory cycle, specifically blocking Substance P and inhibiting PAR-2 receptors to mitigate itching and stinging. It enhances the skin's physical integrity by upregulating involucrin and stimulates the innate immune response via TLR pathways, leading to a significant increase in natural antimicrobial peptides like hBD-2 and cathelicidin.
Research
Clinical Evidence
High confidence0.005%
Key findings
- 01 Demonstrated a 2,121.3% increase in hBD-2 antimicrobial peptide synthesis at a concentration of 0.0003%.
- 02 Achieved a 50% inhibition of pruritus-inducing PAR-2 activation within a 0.003% to 0.01% dose range.
- 03 Validated 66% reduction in skin barrier permeability alongside significant decreases in sensory discomfort (stinging/burning).
Transparency
Dusting Analysis
Because this postbiotic is extremely potent at micro-concentrations, it is rarely 'dusted' in the traditional sense; however, concentrations below 0.0003% may fail to trigger the documented antimicrobial peptide response.
The Formula
Formulation
Stability
Exhibits high stability in aqueous solutions. Best maintained at a skin-neutral pH of 5.5 to preserve peptide bioactivity. Ideally used in airless or sterile packaging to maintain purity without traditional preservatives.
Synergies
- Thermal spring water
- Humectants
- Barrier-repair lipids
Safety
Safety Profile
Extensively tested for 'Sterile Cosmetics' and specifically validated for use on infant, atopic, and highly reactive skin types.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A high-precision postbiotic that offers unparalleled relief for neuro-sensitive and compromised skin barriers through targeted molecular signaling.
Related
Similar Ingredients
Finding similar ingredients…
References
Sources