Science
Mechanism of Action
Operates through a triple-action pathway: it modulates neural signaling by blocking sodium channels and PAR-2 receptors to halt itching, accelerates structural barrier repair by boosting filaggrin and involucrin production, and strengthens innate immunity by inducing antimicrobial peptides and anti-inflammatory cytokines.
Research
Clinical Evidence
High confidence1%
Key findings
- 01 Ex vivo studies demonstrate a 92% inhibition of IL-8 and a 112% reduction in histamine release when stimulated by Substance P.
- 02 A large-scale clinical trial of 5,910 patients showed a 60% decrease in pruritus severity and a 56% reduction in dryness within 7 days.
- 03 Rapid-action study recorded a 55% reduction in skin discomfort (SS-10 score) just 30 seconds after the initial application.
Transparency
Dusting Analysis
Due to its high cost and potent efficacy at low concentrations, brands often include it at trace levels for marketing claims. However, clinical relief of neurogenic itching and significant barrier upregulation typically requires levels closer to 1.0%.
The Formula
Formulation
Stability
This extract contains heat-sensitive proteins and exopolysaccharides; it must be incorporated during the cooling phase of production.
Synergies
- Ceramides
- Panthenol
- Niacinamide
Conflicts
- High heat (>45°C)
- Strong oxidizing agents
- Extreme pH environments (<4.0 or >8.0)
Safety
Safety Profile
Frequently utilized in sterile cosmetic technology to allow for preservative-free formulations, further reducing the risk of secondary irritation for compromised skin.
Your Skin
Skin Compatibility
Our Assessment
Verdict
An elite postbiotic essential for managing sensitive and atopic skin types due to its unique ability to silence neurogenic inflammation and rapidly repair the skin barrier.
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References
Sources