Science
Mechanism of Action
This high-molecular-weight sulfated polysaccharide functions as a superior humectant and film-former. It creates a physical, water-retaining gel lattice on the skin's surface capable of sequestering 6000 times its weight in water. Beyond surface hydration, it acts as a molecular shield against environmental pollutants and mitigates inflammatory responses by suppressing pro-inflammatory cytokines like TNF-α and IL-6.
Research
Clinical Evidence
High confidence0.2%
Key findings
- 01 Clinical evaluation on Asian volunteers demonstrated that a 0.2% concentration increased skin elasticity by 33% and significantly lowered TEWL compared to hyaluronic acid controls.
- 02 A 4-week study on atopic dermatitis subjects using 0.05% reported a marked reduction in itching and improved sleep quality due to symptom relief.
- 03 In vivo modeling at 0.01-0.05% showed potent anti-inflammatory action through the inhibition of COX-2 mRNA expression and neutrophil infiltration.
Transparency
Dusting Analysis
Because Sacran is effective at remarkably low concentrations (as low as 0.01% for anti-inflammatory benefits), it is frequently included at 'label-only' levels. For measurable improvements in skin elasticity and barrier function, levels closer to 0.2% are required.
The Formula
Formulation
Stability
Highly heat stable and resilient in the presence of electrolytes and alcohols up to 50%. It can form liquid crystalline structures when paired with polyols like glycerin.
Synergies
- Glycerin
- Hyaluronic Acid
- Panthenol
Conflicts
- Polysorbates
Safety
Safety Profile
Reviewed and confirmed safe by the CIR under the Polysaccharide Gums group. No known systemic toxicity or irritation concerns.
Your Skin
Skin Compatibility
Our Assessment
Verdict
An elite botanical humectant that provides unparalleled water retention and biological calming effects for compromised or aging skin barriers.
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References
Sources