Science
Mechanism of Action
The extract utilizes high concentrations of iridoid glycosides (such as antirrhinoside) and flavonoids to inhibit pro-inflammatory enzymes COX2 and PGE2. On a cellular level, it acts as an osmoprotectant by preventing the degradation of Hyaluronan Synthase 3 (HAS3), ensuring the skin maintains its natural hyaluronic acid production even under physiological stress.
Research
Clinical Evidence
Medium confidence0.1%
Key findings
- 01 Demonstrated significant radical scavenging and lipid peroxidation inhibition, alongside the maintenance of HAS3 expression for superior hydration retention.
- 02 Exhibited antimicrobial efficacy against common pathogens S. aureus and B. subtilis, supporting its use in barrier-compromised or acne-prone skin.
Transparency
Dusting Analysis
Because biological activity (radical scavenging and HAS3 protection) is documented as low as 0.02%, many brands include it at 'label claim' levels (below 0.01%) that lack physiological impact. Effective formulations should meet or exceed the 0.02% threshold.
The Formula
Formulation
Stability
Highly stable in aqueous systems and standard O/W emulsions within a slightly acidic range. It contains sensitive polar phytochemicals that may undergo color shifts if exposed to extreme pH levels or high oxidative stress.
Synergies
- Hyaluronic Acid
- Glycerin
- Antioxidants (Vitamin C/E)
Conflicts
- Strong oxidizing agents
- High pH environments (>7.0)
Safety
Safety Profile
Passed 24-hour dermatological patch tests and SIRC eye irritation assessments; confirmed non-phototoxic in ROS assays.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A high-precision botanical that bridges the gap between traditional soothing extracts and modern molecular hydration support.
Related
Similar Ingredients
Finding similar ingredients…
References
Sources