Science
Mechanism of Action
This extract operates through a dual-action pathway: it inhibits the denaturation of proteins and suppresses inflammatory mediators via phenolic compounds like apigenin. Simultaneously, it acts as a potent radical scavenger (EC50 of 0.59 mg/mL) to neutralize reactive oxygen species and provide anti-glycation benefits, thereby protecting the skin's structural integrity.
Research
Clinical Evidence
High confidence3%
Key findings
- 01 A 3% concentration was clinically validated via HRIPT to be non-sensitizing and non-irritating for leave-on applications.
- 02 In a 12-week double-blind trial, a 5% concentration demonstrated significant restorative and soothing effects on delicate mucosal tissues.
- 03 Antioxidant efficacy was established at an EC50 of 0.59 mg/mL for DPPH radical scavenging.
Transparency
Dusting Analysis
Often included at symbolic levels (<0.1%) for marketing claims; however, clinical data suggests concentrations between 1% and 3% are required to achieve meaningful anti-inflammatory and barrier-strengthening results.
The Formula
Formulation
Stability
Thermolabile; must be integrated during the cool-down phase below 40°C to maintain flavonoid potency. Requires protection from light and air to prevent oxidative discoloration.
Synergies
- Bisabolol
- Glycerin
- Tocopherol
Conflicts
- Strong oxidizing agents
- Sustained high-temperature processing
Safety
Safety Profile
While generally low-risk, individuals with known allergies to the Asteraceae (daisy) family should exercise caution due to potential cross-reactivity.
Your Skin
Skin Compatibility
Our Assessment
Verdict
An essential botanical for sensitive skin protocols, offering scientifically-backed soothing and antioxidant protection when formulated at active concentrations.
Related
Similar Ingredients
Finding similar ingredients…
References
Sources