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Moumoujus

ANNONA SQUAMOSA FRUIT EXTRACT.

Valuable / SKIN CONDITIONING, SKIN PROTECTING

Derived from the nutrient-dense Sugar Apple, this botanical extract serves as a multi-functional bioactive rich in phenolic compounds and flavonoids. It provides targeted protection against oxidative stress while simultaneously addressing enzymatic pathways associated with skin aging and hyperpigmentation.

Summary

antioxidant skin conditioning collagen protection tyrosinase inhibitor anti-inflammatory

Science

Mechanism of Action

Operates through a multi-pathway approach: it neutralizes reactive oxygen species (ROS) via high concentrations of gallic acid and quercetin equivalents, inhibits the 5-lipoxygenase (5-LOX) enzyme to suppress inflammatory mediators, and downregulates tyrosinase, hyaluronidase, and collagenase activity to preserve the dermal matrix and even skin tone.

Research

Clinical Evidence

Medium confidence
Effective range 0.1–5%
Optimal

1%

Key findings

  1. 01 In vitro analysis (Saroj et al., 2025) demonstrated significant antioxidant potential with an IC50 of 174.9 µg/mL and high efficiency in inhibiting lipid peroxidation.
  2. 02 Bioactive screening (Molecules, 2021) confirmed dose-dependent inhibition of collagenase and hyaluronidase, the primary enzymes responsible for structural skin aging.
  3. 03 Research indicates potent anti-inflammatory modulation via the JAK-1/STAT-3 signaling pathway, reducing cellular stress biomarkers.

Transparency

Dusting Analysis

Commonly dusted
Min. effective
0.1%
Red flag below
0.05%

Botanical extracts like Annona Squamosa are frequently included at concentrations below 0.1% for marketing purposes. To achieve measurable inhibition of tyrosinase and collagenase, a minimum inclusion of 0.5% to 1.0% is recommended.

The Formula

Formulation

Solubility
Water
Optimal pH 4.5 – 6.5
0 7 14

Stability

Highly sensitive to thermal degradation; cold-process manufacturing is essential to preserve bioactive flavonoids. Should be stored in opaque packaging to prevent photo-oxidation.

Synergies

  • L-Ascorbic Acid
  • Vitamin E
  • Ferulic Acid
  • Niacinamide

Conflicts

  • Strong oxidizers
  • High temperature processing (>40°C)
  • Alkaline environments (pH > 7.0)

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
5%
Pregnancy
Safe
Sensitization risk Low

While the fruit is FDA GRAS (Generally Recognized As Safe) for consumption, cosmetic use should focus on pulp-derived extracts; seed-derived extracts may contain undesirable acetogenins.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

A sophisticated botanical antioxidant that offers comprehensive protection against environmental aging and enzymatic degradation when formulated at active concentrations.

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References

Sources