Science
Mechanism of Action
It functions as a CB2 receptor agonist, activating the skin's endocannabinoid system to reduce sensitivity. By down-regulating the TRPV1 inflammatory pathway and the IL-31RA 'itch' receptor, it effectively halts the biological cascade of irritation while using phenolic compounds like rutin and vitamins A and C to neutralize oxidative damage and inhibit tyrosinase activity.
Research
Clinical Evidence
High confidence3%
Key findings
- 01 In a cohort of 117 volunteers, a 3% concentration significantly improved skin comfort and sleep quality by lowering systemic cortisol production.
- 02 A double-blind study demonstrated a 35-60% reduction in skin itchiness within 24 hours of application compared to a placebo.
- 03 Long-term consumer testing showed that 54.5% of users experienced a marked reduction in skin tension after 17 days of consistent use.
Transparency
Dusting Analysis
While many formulations include botanical extracts for marketing purposes at low levels, Annona Cherimola requires a minimum concentration of 3.0% to trigger the neuro-sensory benefits and CB2 activation demonstrated in clinical trials.
The Formula
Formulation
Stability
The extract is thermolabile and must be incorporated during the cooling phase of production (below 45°C) to prevent the degradation of bioactive phenolic compounds.
Synergies
- Niacinamide
- Hyaluronic Acid
- Bisabolol
Conflicts
- Strong acids (pH < 5.2)
- High-heat processing (>45°C)
Safety
Safety Profile
Generally recognized as safe for topical application; its adaptogenic nature makes it particularly suitable for compromised skin barriers.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A sophisticated ingredient for precision skincare that successfully targets the neurological components of skin sensitivity and stress.
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