Science
Mechanism of Action
This ingredient modulates the Nrf2-ARE signaling pathway, upregulating Nrf2 mRNA in keratinocytes to enhance cellular defense against oxidative stress. It also suppresses ROS generation and inhibits Thromboxane B2 release, thereby reducing inflammatory responses.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 ResearchGate (KLHTT study, 2022)
- 02 MDPI (Virtual Screening of Keap1-Nrf2 Inhibitors, 2024)
Transparency
Dusting Analysis
No data available to suggest Angoroside C is commonly dusted; its primary benefit is active efficacy.
The Formula
Formulation
Stability
Angoroside C is water-soluble and generally stable within typical cosmetic pH ranges (4.0-7.0), but sensitive to extreme pH and high temperatures. Its stability can be improved by co-formulating with other antioxidants or using encapsulated delivery systems.
Synergies
- other antioxidants
Conflicts
- Strong oxidizing agents
- Extreme acidic or alkaline environments
Safety
Safety Profile
The CIR has not reviewed Angoroside C. While it is a constituent of traditional medicinal extracts and shows low cytotoxicity in HaCaT keratinocytes, specific safety assessments for its use as a pure cosmetic ingredient are pending.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Angoroside C shows promising in-vitro antioxidant and anti-inflammatory benefits, but further human clinical data and safety assessments are needed to determine its full efficacy and optimal use in skincare.
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References
Sources