Science
Mechanism of Action
This extract primarily brightens skin by inhibiting tyrosinase and melanin production. Its bioactive chalcones and flavonoids offer robust antioxidant defense, neutralizing free radicals and reducing inflammation by suppressing NF-kappaB and MAPKs pathways.
Research
Clinical Evidence
High confidenceN/A
Key findings
- 01 A study demonstrated an 8% concentration inhibited melanin increase in UVB-exposed guinea pig skin as effectively as 4% hydroquinone.
- 02 A general recommended usage range for cosmetic efficacy and safety is 0.1-2% for skin conditioning and antioxidant effects.
- 03 Animal studies showed no acute toxicity, skin irritation, or phototoxicity when using aqueous and ethanol fractions.
Transparency
Dusting Analysis
No specific data indicates that Angelica Keiskei Extract is commonly dusted. Its efficacy is observed within documented concentrations.
The Formula
Formulation
Stability
The extract remains stable in serum gel formulations for at least 28 days at room temperature, maintaining viscosity and homogeneity within a 4.5–6.5 pH range.
Safety
Safety Profile
While not formally reviewed by the CIR Expert Panel, it holds FDA GRAS status for food use (up to 0.834%) and has a history of safe use in traditional Asian medicine. European EFSA also established a safe oral dose.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Angelica Keiskei Extract is a valuable ingredient, demonstrating robust skin-brightening and antioxidant benefits with a favorable safety profile across various skin types.
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References
Sources