Science
Mechanism of Action
The extract reduces hyperpigmentation by inhibiting tyrosinase synthesis and acts as an anti-inflammatory via NF-κB/MAPK pathways. It also accelerates keratinocyte proliferation, aiding in wound healing.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Accelerated human keratinocyte proliferation for wound healing, downregulating cyclin D1 (0.5 mg/mL).
- 02 Achieved 61.12% tyrosinase inhibition in a composite formulation, suggesting melanin suppression (8 mg/mL).
- 03 Demonstrated 81% free radical scavenging in facial liquids, confirming potent antioxidant activity (2.0 mg/mL).
- 04 Suppressed atopic dermatitis-like lesions and reduced IgE/histamine levels in mouse models (10 mg/day topical).
Transparency
Dusting Analysis
This ingredient is not commonly identified as being 'dusted' in cosmetic formulations.
The Formula
Formulation
Stability
Flavonoids are stable in acidic conditions (pH 3-4), while the overall extract is stable up to neutral pH (7.0). It is sensitive to heat above 70°C and direct sunlight due to photosensitive coumarins.
Conflicts
- UVA radiation (induces phototoxicity)
- Strong oxidizing agents
- Warfarin (potential systemic interaction if absorbed)
Safety
Safety Profile
Contains furanocoumarins, known photosensitizers and potential photocarcinogens upon UVA exposure. Water extraction minimizes these, but sunscreen use is crucial.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Angelica Dahurica Extract is a valuable multi-functional ingredient, offering brightening, soothing, and antioxidant benefits, but requires careful formulation and use due to photosensitivity.
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References
Sources