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Moumoujus

ANGELICA ARCHANGELICA LEAF EXTRACT.

Valuable CAS 84775-41-7 / ASTRINGENT, TONIC

Angelica archangelica leaf extract offers multi-functional skin benefits, primarily preventing photoaging by inhibiting collagen degradation and providing potent antioxidant protection. It also enhances skin hydration and radiance, while possessing antimicrobial and anti-inflammatory properties.

Summary

astringent tonic skin conditioning soothing

Science

Mechanism of Action

This extract primarily inhibits Matrix Metalloproteinases (MMPs) and modulates MAPK/AP-1 pathways to combat photoaging and collagen breakdown. It further improves skin hydration by stimulating Aquaporin 3 (AQP3) expression and provides anti-inflammatory and antimicrobial effects via furanocoumarins.

Research

Clinical Evidence

Medium confidence
Effective range 0.001–2%
Optimal

N/A

Key findings

  1. 01 PubMed (PMID: 26363453): Inhibition of UVB-induced MMPs, preventing collagen degradation.
  2. 02 Newthingsbio.com: Antioxidant capacity, circulation enhancement, improved radiance and age spots reduction.
  3. 03 ResearchGate: Potent antioxidant protection against lipid peroxidation.

Transparency

Dusting Analysis

Not commonly dusted

Efficacy is observed across a broad dose range, from very low concentrations for molecular effects to higher percentages for antioxidant protection. The noted maximum concentration of 0.78% is a safety guideline related to furanocoumarins, not an indication of efficacy limits.

The Formula

Formulation

Solubility
Both
Optimal pH 4 – 6.5
0 7 14

Stability

Extracts are sensitive to light and heat due to volatile terpene content; vacuum or cold processing is preferred to maintain bioactive integrity.

Conflicts

  • Strong oxidizing agents
  • High UV exposure (increases phototoxic potential)
  • Strongly alkaline environments

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
0.78%
Sensitization risk Moderate

While not reviewed by CIR for leaves, IFRA and SCCS monitor furanocoumarin content for phototoxicity. Leave-on products may have concentration restrictions.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

A multi-functional extract offering significant antioxidant and anti-aging benefits, particularly effective in preventing collagen degradation and improving skin hydration, though careful formulation is needed due to potential phototoxicity at higher concentrations.

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