Science
Mechanism of Action
As a chemosignal, it targets the vomeronasal organ and olfactory epithelium, modulating the hypothalamus and autonomic nervous system. This interaction influences mood, stress levels, and social perception.
Research
Clinical Evidence
Medium confidence0.000135%
Key findings
- 01 Subthreshold exposure (0.000135%) reduced aggression in men and enhanced mood in women.
- 02 Direct administration of 100 pg to the vomeronasal organ reduced nervousness and negative feelings in females.
Transparency
Dusting Analysis
As a specialized chemosignal, Androstadienone is effective in minute quantities for its olfactory effects, making traditional 'dusting' irrelevant to its application.
The Formula
Formulation
Stability
Highly lipophilic, stable in anhydrous oil-based systems or ethanol. Susceptible to oxidative degradation without antioxidants. Often diluted in propylene glycol or essential oils.
Conflicts
- strong oxidizing agents
- strong acids
- highly alkaline environments
Safety
Safety Profile
There is no specific CIR or SCCS safety assessment. It's primarily regulated as a fragrance, with FDA status 'not determined' for systemic or dermal toxicity in cosmetics.
Your Skin
Skin Compatibility
Our Assessment
Verdict
While showing behavioral effects as a pheromone, direct skin efficacy and comprehensive safety data for cosmetic applications are currently insufficient.
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References
Sources