Science
Mechanism of Action
It inhibits NF-κB, JNK, and JAK2/STAT3 pathways to reduce inflammation and acts as an antioxidant. For brightening, it suppresses melanin production by inhibiting TYR and MITF proteins.
Research
Clinical Evidence
High confidence2%
Key findings
- 01 ThaiJO (2025); Adam et al. (2022)
- 02 PubMed Central (2025); PMC11281511
- 03 MDPI (2020); Mussard et al.
Transparency
Dusting Analysis
No specific data suggests this ingredient is commonly dusted. It shows efficacy at clinically relevant concentrations.
The Formula
Formulation
Stability
Andrographolide is highly unstable in alkaline and aqueous environments, undergoing degradation. Optimal stability is achieved at lower temperatures and acidic pH 3-5.
Conflicts
- Alkaline environments
- Aqueous solutions without stabilization
- High temperatures
Safety
Safety Profile
Generally considered to have low toxicity in topical applications, with studies showing good patient tolerance up to 2% concentration. It is not listed as restricted by FDA or SCCS.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Andrographolide offers significant anti-inflammatory, antioxidant, and skin brightening benefits, making it a valuable ingredient for various skin concerns.
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References
Sources