Science
Mechanism of Action
Its active compounds, diterpene lactones, reduce inflammation and oxidative stress. It also stimulates collagen synthesis, enhances epidermal stem cell activity, and inhibits melanin production by suppressing tyrosinase.
Research
Clinical Evidence
High confidenceN/A
Key findings
- 01 You et al., PMCID: PMC7243224 / NIH
- 02 Fabbrocini et al. (2018), cited in PMC6247544
Transparency
Dusting Analysis
No data available regarding commonly dusted practices for this ingredient.
The Formula
Formulation
Stability
The key active, andrographolide, is poorly water-soluble but dissolves in ethanol and organic solvents. While stable as a crystalline solid up to 70°C, it can degrade in aqueous solutions, showing a 26-32% reduction in lactones over 9-12 months.
Conflicts
- Strong oxidizing agents
- Highly alkaline environments
Safety
Safety Profile
Generally safe for topical use, with clinical trials showing good tolerance. Rare hypersensitivity is reported for oral use.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This ingredient is valuable for its multifunctional benefits, addressing aging, pigmentation, and inflammation with good skin compatibility.
Related
Similar Ingredients
Finding similar ingredients…
References
Sources