Science
Mechanism of Action
Its primary active, andrographolide, strengthens the dermo-epidermal junction by boosting collagen and laminin while reducing MMP-9. It also inhibits melanin production via tyrosinase suppression and offers antioxidant defense against UVB damage.
Research
Clinical Evidence
Medium confidence2%
Key findings
- 01 Phoo Mon et al. (2025), Procedia of Multidisciplinary Research
- 02 Adam et al. (2022)
Transparency
Dusting Analysis
No data available in the provided research to suggest this ingredient is commonly dusted in formulations.
The Formula
Formulation
Stability
The extract and its active compounds are sensitive to high heat, extreme pH, and oxidation. It is poorly water-soluble but dissolves well in ethanol and glycols, typically supplied in glycerin/water bases.
Conflicts
- Strong oxidizing agents
- Extreme pH environments (>8 or <3)
- Strongly alkaline formulations
Safety
Safety Profile
While CIR has not reviewed it, clinical trials up to 2% show no adverse skin reactions. Oral safety is established, but topical safety data is limited to individual studies.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Andrographis Paniculata Extract is a promising multi-functional ingredient with documented benefits for anti-aging, brightening, and soothing across all skin types, demonstrating good safety at recommended concentrations.
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References
Sources