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AMYL BUTYRATE.

Optional CAS 540-18-1 / PERFUMING

Amyl Butyrate is a fruity-scented fragrance ingredient. In vitro studies indicate its potential to modulate inflammatory responses in the skin by activating specific olfactory receptors.

perfuming fragrance anti-inflammatory

Science

Primarily functions as a perfuming agent. Biologically, it is an agonist for the ectopic olfactory receptor OR2AG1, which can influence calcium signaling and counteract histamine-induced pathways, potentially soothing reactive skin.


Research

Medium confidence
Effective range 0.1–1%
Optimal

0.5%

Key findings

  1. 01 Kalbe B, et al. (2016). Olfactory Receptors Modulate Physiological Processes in Human Airway Smooth Muscle Cells.
  2. 02 Api AM, et al. (2020). RIFM fragrance ingredient safety assessment, amyl butyrate.

Transparency

Not commonly dusted

No specific data on dusting or powder form issues were found in the research.


The Formula

Solubility
Oil
Optimal pH 6 – 7.5
0 7 14

Stability

A highly volatile ester, stable under normal conditions but susceptible to hydrolysis in strong acidic or alkaline environments. Store in a cool, dark place to prevent oxidation.

Conflicts

  • Strong oxidizing agents
  • Strong acids
  • Strong bases

Safety

CIR Status
Safe as used
Max tested
8%
Sensitization risk Low

The CIR Expert Panel concluded it is safe when formulated to be non-irritating, reviewing it within the Alkyl Esters group.


Your Skin

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Optional

Amyl Butyrate is a safe fragrance ingredient with potential anti-inflammatory properties, making it an interesting addition for sensitive and reactive skin types, primarily for its scent.


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