Science
Mechanism of Action
It inhibits pro-inflammatory cytokines and the NF-κB pathway, while polyphenols provide antioxidant and tyrosinase-inhibiting effects to reduce melanin. It also modulates growth factors like TGF-β1 and VEGF for enhanced tissue regeneration.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 20% ethanol extract significantly reduced wound size and promoted tissue regeneration in a rat scald model (PMC, 2016).
- 02 Topical 30 mg/kg ethanol extract reduced scaling and erythema in contact dermatitis models, comparable to dexamethasone (ResearchGate, 2022).
- 03 Acetone extracts showed potent anti-tyrosinase and anti-melanogenic activity with an IC50 of 8.30 μg/mL (MDPI, 2022).
Transparency
Dusting Analysis
No explicit data suggests this ingredient is commonly dusted in cosmetics. Its potent bioactive profile indicates efficacy at lower, non-dusting concentrations.
The Formula
Formulation
Stability
Its polyphenolic compounds are sensitive to light and oxidation. Optimal extraction and stable incorporation often require glycols or emulsifiers due to poor solubility in pure water.
Conflicts
- Strong oxidizing agents
- Strongly alkaline environments (pH > 8.0)
- Metal ions
Safety
Safety Profile
While not formally reviewed by the CIR, it has a history of safe traditional use and animal studies indicate low toxicity. High concentrations mentioned in studies are typically for medical applications.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This multi-functional botanical extract is a valuable ingredient for addressing concerns like inflammation, hyperpigmentation, and skin healing due to its well-documented traditional use and promising preliminary research.
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References
Sources