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Ingredient directory

Ammonium Nonoxynol-4 Sulfate

An anionic surfactant that combines cleansing and emulsifying properties through its dual-soluble molecular structure. This ingredient excels at removing sebum and impurities from skin surfaces by lowering oil-water surface tension, making it particularly effective in rinse-off formulations.

Directory entry · Individual source review pending

This profile is awaiting an individual source review. Treat its ratings, dose estimates and compatibility labels as provisional; they are not medical advice or proof of a finished product’s effects.

cleansing surfactant emulsifying

Science

Functions as a surfactant through its amphiphilic structure featuring a hydrophobic nonylphenol tail and hydrophilic sulfate head group. This molecular architecture enables it to reduce surface tension between oil and water phases, effectively emulsifying sebum and debris for easier removal from the skin surface.


Research

Medium confidence
Effective range ≤5%
Optimal

N/A

Key findings

  1. 01 CIR assessment demonstrates safety profile for nonoxynol compounds 1-8 at concentrations up to 5% in leave-on applications

Transparency

Not commonly dusted

As a functional surfactant with specific cleansing properties, this ingredient is unlikely to be used for dusting purposes in skincare formulations.


The Formula

Solubility
Both
Optimal pH 4 – 7
0 7 14

Stability

Maintains stability in neutral to mildly alkaline conditions; aqueous solutions may experience pH drift over time. The n=4 ethoxylation level provides balanced oil and water solubility characteristics.

Conflicts

  • Strong oxidizing agents
  • Highly acidic environments
  • Cationic surfactants

Safety

CIR Status
Safe with restrictions
Max tested
5%%
Sensitization risk Moderate

Approved for rinse-off applications with 5% concentration limit for leave-on products due to irritation potential. Environmental persistence and potential 1,4-dioxane contamination require consideration.


Your Skin

Yes Normal
No Dry
Yes Oily
No Sensitive
Irritancy Moderate
Comedogenicity Low

Our Assessment

Optional

A competent cleansing surfactant best suited for oily and normal skin types in rinse-off formulations, with moderate irritation potential limiting its versatility.


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