Science
Mechanism of Action
Functions through multi-pathway inflammatory modulation by blocking phospholipase A2 and cyclooxygenase enzymes to reduce prostaglandin formation. Additionally inhibits 11β-hydroxysteroid dehydrogenase type 2, preventing cortisol breakdown and maintaining elevated local anti-inflammatory cortisol levels. Further suppresses hyaluronidase activity and NF-κB activation pathways.
Research
Clinical Evidence
High confidence5%
Key findings
- 01 Demonstrated no skin irritation or sensitization potential in clinical testing on healthy volunteers
- 02 Confirmed absence of phototoxicity and photosensitization effects in human subjects
Transparency
Dusting Analysis
Well-established ingredient with clear regulatory approval and defined usage parameters, making dusting unnecessary
The Formula
Formulation
Stability
Forms rod-like micelles in weakly acidic solutions around pH 5.0. Achieves optimal stability at pH 5.77 with dramatically improved solubility above pH 4.0. Compatible with glycerin and propylene glycol but insoluble in oil phases.
Synergies
- Glycerin
- Propylene glycol
- Other water-soluble soothing agents
Conflicts
- Strong acids causing glycyrrhizic acid precipitation
- High-concentration anionic surfactants
- Highly alkaline formulations
Safety
Safety Profile
CIR Expert Panel confirms safety in current usage practices. Minimal skin absorption noted. Quality control should monitor heavy metal residues (Lead <1mg/kg) due to botanical origin.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A well-researched, multi-mechanism anti-inflammatory with excellent safety profile and universal skin type compatibility.
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References
Sources