Science
Mechanism of Action
Combining 5-aminolevulinic acid (ALA) and Pentapeptide-6, it targets sebocytes to reduce oxidative stress. This modulates heme biosynthesis and cellular signaling pathways, normalizing sebum output and conditioning the skin.
Research
Clinical Evidence
Medium confidence0.5%
Key findings
- 01 At 0.5% concentration, in-vitro studies demonstrated a significant reduction in Reactive Oxygen Species (ROS) and inhibition of sebum production. Clinical observation indicated effectiveness in controlling oily skin and mild acne symptoms when used synergistically with other antioxidants.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The peptide linkage is sensitive to extreme pH levels and high temperatures. Incorporate it during the cooling phase of an emulsion, below 40°C.
Synergies
- Other antioxidants
Conflicts
- Strong oxidizing agents
- Highly acidic environments (pH < 4.0)
- Proteolytic enzymes
Safety
Safety Profile
Listed as an antioxidant in the EU CosIng database. Generally considered safe at typical cosmetic use levels (0.01% - 1.0%) with low irritancy.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This precision lipopeptide offers targeted antioxidant defense and sebum regulation, making it a valuable asset for balancing skin and addressing mild acne symptoms.
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