Science
Mechanism of Action
As a matrikine peptide, it stimulates fibroblasts to boost production of collagen (Types I, III, IV), elastin, fibronectin, and GAGs. It also inhibits collagenase activity, actively preventing matrix degradation.
Research
Clinical Evidence
High confidence0.0003%
Key findings
- 01 At 0.0003%, significant improvement in wrinkle depth and volume was observed, comparable to 0.07% retinol with superior tolerability.
- 02 Concentrations of 3.0% and 7.0% successfully reduced periorbital wrinkles within 6 and 3 months, respectively, with minimal side effects.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Typically used as an oil-soluble 'Palmitoyl' version for enhanced skin penetration, often within glycerin/water/butylene glycol solutions. Stable at room temperature; avoid high heat during manufacturing.
Conflicts
- Strong acids
- Strong oxidizing agents
- Proteolytic enzymes
Safety
Safety Profile
The CIR Expert Panel confirmed its safety under current usage practices (2024 Final Report). Highest reported use in eye makeup was 0.05%.
Your Skin
Skin Compatibility
Our Assessment
Verdict
An effective and well-tolerated peptide ideal for precision anti-aging formulations targeting wrinkles and overall skin rejuvenation.
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References
Sources