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AMIDINOPROLINE.

Valuable CAS 35404-57-0 / FRAGRANCE, HUMECTANT, PERFUMING, SKIN CONDITIONING

Amidinoproline is an N-amidino-L-proline derivative, a specialty skin-conditioning and firming ingredient primarily researched by Kao Corporation. It visibly reduces fine wrinkles caused by dryness and significantly improves skin plumpness.

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Science

This ingredient functions as a 'moisture lift' agent, penetrating deep into the stratum corneum to target keratin fibers. By helping these fibers retain moisture, it prevents hardening and shrinking, thereby plumping the skin and increasing elasticity and firmness.


Research

High confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 In vivo efficacy tests demonstrated a significant reduction in the appearance of fine wrinkles caused by dryness and improved skin plumpness.
  2. 02 Shown to penetrate the stratum corneum, delivering 'Moisture Lift' effects by targeting dehydrated keratin fibers to restore elasticity.

Transparency

Not commonly dusted

The Formula

Solubility
Water
Optimal pH 5 – 7
0 7 14

Stability

Generally stable in aqueous solutions, amidine-type structures can be sensitive to extreme hydrolysis in highly acidic environments (typically below pH 4.0).

Conflicts

  • Strongly acidic environments (< pH 4.0)
  • Strong oxidizing agents

Safety

CIR Status
Not reviewed
Sensitization risk Low

Though not individually reviewed by the CIR, this amino acid derivative has a long history of safe use in Japanese 'Quasi-Drug' and standard cosmetic anti-aging formulations.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

Amidinoproline is a valuable skin-conditioning agent, clinically shown to enhance skin plumpness and reduce fine wrinkles by improving stratum corneum hydration and elasticity.


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